Direct flights to Owen Roberts International Airport, Grand Cayman from the following locations:-
| FROM: | DURATION: | AIRLINES: |
| Miami, FL | 1h 20m | American Airlines & Cayman Airways |
| Charlotte, NC | 2h 54m | US Airways |
| Atlanta, GA | 2h 47m | Delta |
| Chicago | 4h 55m | Cayman Airways |
| Detroit, MI | 4h 3m | Delta |
| Houston, TX | 2h 47m | Continental Airlines |
| Minneapolis, MN | 4h 13m | Delta |
| New York | 4h 8m | Continental Airlines & Cayman Airways |
| Philadelphia, PA | 3h 52m | US Airways |
| Tampa, FL | 2h 40m | Cayman Airways |
| Washington, DC | 3h 56m | Cayman Airways |
| Toronto, Canada | 3h 56m | WestJet & Air Canada |
| Nassau, Bahamas | 3h 35m | British Airways |
| London, UK (via Nassau) | 11h | British Airways |
| Havana, Cuba | 2h | Cayman Airways |
| Kingston, Jamaica | 1h | Cayman Airways |
| Montego Bay, Jamaica | 45m | Cayman Airways |
| La Ceiba, Honduras | 55m | Aerolineas Sosa & Cayman Airways |
| Little Cayman | 35m | Cayman Airways |
| Cayman Brac | 40m | Cayman Airways |
Dallas di..